By W.P. Kaschka, D. Rujescu, W.F. Gattaz
Suicide is without doubt one of the most vital reasons of loss of life in sleek societies. To strengthen better preventive measures, we need to pay attention to and examine extra approximately its neurobiological foundations. lately, the instruments of contemporary neurosciences have more and more been applied to symbolize the pathophysiology of complicated human behaviors comparable to suicide. to enhance suicide probability evaluate and suicide prevention, a greater realizing of its pathophysiology is important. This comprises learn from quite a few disciplines reminiscent of neuropsychological, psychosocial and cultural experiences but in addition findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. very important effects have, for instance, been bought within the box of gene-environment interplay and suicidal habit. we've got simply began to appreciate how early-life adversity may well raise suicide hazard via epigenetic mechanisms. in accordance with such insights, novel healing interventions and preventive measures might be constructed. in addition, a greater knowing of the pathophysiological mechanisms keen on suicidal habit may display the mechanism of compounds like lithium salts. during this ebook, suicidal habit and its prevention is mentioned via foreign specialists within the gentle of the latest effects from a extensive spectrum of neurosciences.
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Extra info for Biological Aspects of Suicidal Behavior (Advances in Biological Psychiatry, Vol. 30)
64 Pandey GN, Dwivedi Y, Ren X, Rizavi HS, Roberts RC, Conley RR, Tamminga C: Altered expression and phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in postmortem brain of suicide victims with or without depression. J Psychiatr Res 2003; 37:421–432. 65 Dwivedi Y, Conley RR, Roberts RC, Tamminga CA, Pandey GN: [3H]cAMP binding sites and protein kinase A activity in the prefrontal cortex of suicide victims. Am J Psychiatry 2002; 159: 66–73. 66 Dwivedi Y, Rizavi HS, Shukla PK, Lyons J, Faludi G, Palkovits M, Sarosi A, Conley RR, Roberts RC, Tamminga CA, Pandey GN: Protein kinase A in postmortem brain of depressed suicide victims: altered expression of specific regulatory and catalytic subunits.
38 Pandey GN, Ren X, Rizavi HS, Conley RR, Roberts RC, Dwivedi Y: Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in postmortem brain of teenage suicide victims. Int J Neuropsychopharmacol 2008; 11:1047–1061. 39 Black C, Miller BJ: Meta-analysis of cytokines and chemokines in suicidality: distinguishing suicidal versus nonsuicidal patients. Biol Psychiatry 2015;78: 28–37. 40 Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, Brundin L: Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.
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