Atlas of Osteoporosis by Eric S. Orwoll, Robert Marcus (auth.), Eric S. Orwoll MD

By Eric S. Orwoll, Robert Marcus (auth.), Eric S. Orwoll MD (eds.)

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Bane Miner Res 1996,11:1841-1849. 27. } Bane Miner Res 1995, 10:978-984. 28. } Bane Miner Res 1997, 12: 1049-1 057. 29. } Bane Miner Res 1997, 12:915-921. 30. } Bane Miner Res 1996, I I: 1850-1855. 31. } Bane Miner Res 1997,12:1043-1048. 32. } Bane Miner Res 1999, 14: 1379-1386. 33. : Absence of linkage for bone mineral density to chromosome 12q 12-14 in the region of the vitamin D receptor gene. ColeifTissue Int 2000,67:434-439. 34. Kelly Pj: Is osteoporosis a genetically determined disease?

This can be carried out with aseries of polymorphie genetic markers. It is less suitable for the study of complex diseases. such as osteoporosis where multigeneration families are difficult to come by and the mode of inheritance for the disease is unclear. This approach does not involve construceing a model of disease inheritance and, because of this. has been widely used in genetic mapping of complex diseases. A potential pitfall with such studies is that they can give spurious results due te population stratification.

Kelly PJ, Eisman JA, Sambrook PN: Interaction of genetic and environmental influences on peak bone density. Osteoporosis Int 1990, I :56-60. 6. } Bone Miner Res 1993,8: 1-9. 7. Villa ML, Nelson L, Nelson D: Race, ethnicity, and osteoporosis. In Osteoporosis, vol I, edn 2. Edited by Marcus R, Kelsey J, Feldman D. San Diego: Academic Press; 200 I :569-584. 8. Gilsanz V. } Clin Endocrinol Metab 1998,83: 1420-1427. 9. See man E: Growth in bone mass and size: Are racial and gender differences in bone mineral density more apparent than real?

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