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Extra resources for Antirheumatic Therapy: Actions and Outcomes (Progress in Inflammation Research)
Arthritis Rheum 35 (10): 1117-1125 25 Suarez-Almazor ME, Osiri M, Emery P, Ottawa Methods Group (2004) Rheumatoid arthritis. In: Tugwell P, Shea B, Boers M, Brooks P, Simon LS, Strand V et al (eds): Evidence-based rheumatology. BM] Publishing Group, London, 243-314 26 Gotzsche PC, Podenphant ], Olesen M, Halberg P (1992) Meta-analysis of second-line antirheumatic drugs : sample size bias and uncertain benefit . J Clin Epidemiol 45 (6): 587-594 27 Haagsma C], van Riel PL, de long A], van de Putte LB (1997) Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: a randomized, controlled, double-blind, 52 week clinical trial.
OJ: .. O : ' , + i. ~)L __ j r------~---J--------- I L I 0 .. ~);c L. 8 _ _ .. 8 (minocycline)) and a positive charge of the dimethyl ammonium groups (pKa). be noted at this point. The term, tetracyclines, is applied to the group of antibiotics, while tetracycline is a specific compound. Minocycline is a semi-synthetic tetracycline that contains two dimethyl amino groups as opposed to the single dimethylamino group in tetracycline (Fig. 11). Tetracycline and dox ycycline have not been found to have anti-rheumatic activity but further work would be required to disprov e their clinical utility.
In a classical experiment by Tversky and Kahneman, respondents were presented with two differently worded scenarios, but with identical expected outcomes . The problem stated that an Asian disease was expected to kill 600 people. In the first scenario, respondents had to choose between program A, which would save 200 people, or program B, with which there was a one-third probability that 600 people would be saved, and twothirds probability that no people would be saved. Most respondents (72 %) were risk averse, and chose program A.