Ankylosing spondylitis and Klebsiella by Alan Ebringer

By Alan Ebringer

Ankylosing spondylitis and Klebsiella is a entire and informative textual content at the reason for Ankylosing spondylitis. Ankylosing spondylitis (AS) is a which impacts 20 million humans around the world and is probably going prompted or initiated via a bowel an infection from Klebsiella bacteria.


When a sufferer is contaminated by means of Klebsiella bacteria, his or her immune process will make antibodies opposed to the entire antigens or molecules present in the microbe. simply because a few of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but in addition the self tissues akin to the joints and the cells having a similar HLA molecules, that's how the illness AS starts.  this can be the concept that of molecular similarity or “molecular mimicry” which formerly has been chanced on to paintings in different autoimmune illnesses; rheumatic fever and rheumatoid arthritis.


The first paper in this topic used to be released in 1976 and because then over a hundred papers on rheumatological themes were released, from Prof Ebringer’s workforce, on the department of lifestyles Sciences, King’s university in London, united kingdom.


The appropriate details from those papers is extracted and awarded during this publication layout making it available to wellbeing and fitness pros, learn associations, pharmaceutical businesses and universities and most people.

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Extra info for Ankylosing spondylitis and Klebsiella

Sample text

This book describes an attempt to solve the problem of the link between HLA-B27 and ankylosing spondylitis. 8 The Middlesex Hospital in London1 The first Middlesex Hospital opened in 1745 as the Middlesex Infirmary in Windmill street London W1. The second Middlesex Hospital opened in 1757 in Mortimer street and was incorporated by an Act of Parliament in 1836. The new building was opened in 1935, by the Duke of York, later to become King George VI. 1 History of the Middlesex Hospital previously appeared in Rheumatoid Arthritis and Proteus, with permission.

30 4 Molecular Mimicry Between HLA-B27 and Klebsiella Bacteria 40 Bound % 30 20 Klebsiella 10 B-27 Iymphocytes(Rabbit B) B-27 Iymphocytes(Rabbit A) Control 0 1 2 3 Reciprocal dilution × 10-3 Fig. 2 Comparison of rabbit antisera raised against HLA-B27 lymphocytes (A and B), Klebsiella pneumoniae microorganisms and pooled serum from three unimmunised rabbits (control) in a KlebsiellaSP-125I-binding assay. 3 % for the pooled control serum. 05) in binding Klebsiella SP-125I compared to sera obtained from rabbit E before and after immunisation with an equal quantity of non-B27 lymphocytes which did not show any increased binding.

Transplantation. 1973;15:441–5. Kaplan MH, Meyeserian M. An immunological crossreaction between Group A Streptococcal cells and human heart. Lancet. 1962;1:706–10. Rowley D, Jenkin CR. Antigenic crossreaction between host and parasite as a possible cause of pathogenicity. Nature. 1962;193:151–4. Whittingham S, Mackay IR. Tissue antigens: autoantigens, alloantigens xenoantigens and neoantigens. Aust N Z J Med. 1977;7:172–94. 1 Introduction: Involvement of Muscle Pathology in Ankylosing Spondylitis Ankylosing spondylitis patients attending the ‘Ankylosing Spondylitis Research Clinic of the Middlesex Hospital’ complained frequently of muscle stiffness and pain.

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