Ageing Vulnerability: Causes and Interventions - No. 235 by Novartis Foundation

By Novartis Foundation

With the ever-increasing upward thrust in existence expectancy, there's an pressing have to enhance our realizing of the connection among getting older and the pathogenesis of age-related illnesses which will determine more suitable technique of prevention, amelioration and administration of such illnesses. furthermore, there's a have to lessen the social and fiscal impression of the growing older inhabitants. Age-related morbidity and mortality vary dramatically between members; this publication focusses on person alterations in susceptibility to age-related problems.

It includes contributions from best specialists within the box on issues such as:
age-related pathology within the mind, age-related tactics in stem cells, and age-related results at the immune approach and in bone, muscle and cardiovascular tissue.

For all people with an curiosity within the biology of ageing, this is often obligatory reading.

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Extra info for Ageing Vulnerability: Causes and Interventions - No. 235

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Furthermore, the deposition of Ab in the neocortex of transgenic mice overexpressing human Ab peptides is accompanied by many of the neuropathological features of AD, including intraneuronal tau abnormalities and neuronal loss, as well as signs of oxidative damage similar to those seen in ADa¡ected brain (Calhoun et al 1998). The length of the di¡erent Ab species is considered to be one important factor in AD pathogenesis. Human Ab1^40 is the principal species present in the brain and elsewhere.

Perhaps this needs to be reanalysed. Having said this, in our own experiments in which we control for this we still see an increase of aluminium in the tissue, but we see this in both aged and AD cases: there is no 42 DISCUSSION di¡erence between the AD cases and the controls. We are unsure of the signi¢cance of this. Kirkwood: My other question concerns the broader implications of the suggested antioxidant role of soluble amyloid. Within other tissues, do you see any evidence for correlated antioxidant functions?

Robert: A few years ago at any meeting on AD, there were many people who thought that shorter Ab was good for the neurons. Over a decade or so the ratio of people who thought it was good versus those who thought it was bad has progressively shifted in favour of those who think it was bad. What about the shorter variant? Does it have neurotrophic activity? Secondly, how do you explain the 10% of familial AD cases? Bush: The very ¢rst papers about the neurotoxicity of Ab were published by Bruce Yankner in 1989 and 1990.

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