Advances in Alzheimer's and Parkinson's Disease: Insights, by Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel

By Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin

Proceedings of the seventh foreign convention on Alzheimer’s illness and Parkinson’s illness (ADPD), held March 9-13, 2005 in Sorrento, Italy.

The subject material of the ADPD meetings is exclusive in that it offers not just with concerns similar separately to Alzheimer’s sickness and Parkinson’s ailment, but in addition with the combination of those and different similar ailments. the main updated innovations and study findings are illustrated during this quantity, protecting subject matters similar to immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the background, epidemiology, scientific phenomenology, analysis, imaging, therapy ,and destiny views of Alzheimer’s and Parkinson’s Diseases.

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37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. Chapter 3 Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity Simona Francisconi, Mara Codenotti, Erminia Poli, Daniela Uberti, Giulia Ferrari-Toninelli, and Maurizio Memo Introduction Preservation of genomic stability is an essential biological function, and cells engage efficient mechanisms to maintain DNA stability over time and prevent the generation and the persistence of impaired cells that may be detrimental to the organism.

14 Y. Mizuno, N. Hattori LRRK2 protein belongs to the ROCO protein family. ROCO proteins are a group of proteins that have ROC and COR domains [64]. ROC stands for Ras of complex proteins and COR stands for carboxy-terminal of ROC. In addition, many ROCO proteins have an LRR (leucine-rich repeat) domain, an MAPKKK (mitogen-induced protein kinase kinase kinase) domain, and a WD domain, which is rich in tryptophan and aspartate repeats. The function of LRRK2 is still unknown; but because it has a protein kinase domain, it is likely that its role is phosphorylation of proteins that are important for the survival of nigral neurons.

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